Published Resources Details
Thesis
- Title
- Some aspects of circulatory control during arterial hypoxia in the unanaesthetized rabbit
- Description of Work
- PhD
- Imprint
- University of New South Wales, Sydney, Australia, 1966
- Url
- https://doi.org/10.26190/unsworks/12550
- Format
- Contains
- Image
- Description
This thesis was added to UNSWorks as part of a retrospective digitisation program. Minor variation from the print version may occur as a result of the scanning process. Affiliation: Physiology, Faculty of Medicine, UNSW.
- Abstract
The present study was undertaken in order to examine the role of afferent and efferent mechanisms and of local factors in the control of the circulation during acute arterial hypoxia in the unanaesthetized rabbit and to try to reach a better understanding of the manner in which these various factors interact. The experiments were designed to examine in detail the relative roles of the carotid and aortic receptor regions during hypoxia, to relate excitation of these receptors to activation of the sympatho-adrenal pathways involved in the circulatory response, and to examine the local effects of hypoxia on the peripheral circulation in the absence of extrinsic neurohumoral control. The use of an unanaesthetized preparation is particularly suitable for this sort of investigation since it permits assessment of the role of the efferent mechanisms when reflexly activated by stimulation of the afferent pathways under normal physiological conditions.